Being a Chelsea fan, I always start every new version of C/FM managing them, and it is an attractive prospect, not so much for the big players that we signed (Sheva and Ballack) because their ages will make them not so useful in FM terms, but to see what they do with the young stars like Mikel and Kalou.
The team I am most looking forward to, however, is Lyon. They were great fun in the last version, and now that the likes of Malouda, Abidal, Govou etc should have been raised in standard so as to be more inline with their world cup performances, it should be a really awesome team to manage.
Villarreal have always been one of the most fun teams to manage, and this should be no exception. Werder Bremen also look like a cool start to a team with lots of room for building. In terms of lower leagues, Gretna have got to be a challenge, with Europe straight away, Accrington Stanley also, looking forward to trying to bring them up through the leagues, and also, of course, those Italian teams which got relegated for their dodgy activity. Their players which didnt leave will also flood the FM transfer market with interesting talent.